There is no syscall surface to attack because the code never makes syscalls. Memory safety is enforced by the runtime. The linear memory is bounds-checked, the call stack is inaccessible, and control flow is type-checked. Modern runtimes add guard pages and memory zeroing between instances.
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By the time Sanger sequencing was commercialized, the groundwork for an entirely new sequencing chemistry was already well underway. In 1985, Swedish biochemists Pål Nyren and Arne Lundin published a paper illustrating a procedure that measured the concentration of a molecule, called pyrophosphate (PPi), using an enzymatic cascade that emits light. In early 1986, Nyren realized that the method he’d helped develop could be applied to DNA sequencing, because PPi is naturally produced as a byproduct of DNA synthesis.5