Of course, the glue code also has runtime costs. JavaScript objects must be allocated and garbage collected, strings must be re-encoded, structs must be deserialized. Some of this cost is inherent to any bindings system, but much of it is not. This is a pervasive cost that you pay at the boundary between JavaScript and WebAssembly, even when the calls themselves are fast.
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Source: Computational Materials Science, Volume 267
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